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Mouse Monoclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, E, Flo |
|---|---|
| Primary Accession | P08648 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone Names | 10F6 |
| Calculated MW | 115kDa |
| Dilution | Flo (1:200-1:400), IHC-P (1:200), WB (1:500-1:2000) |
| Gene ID | 3678 |
|---|---|
| Other Names | Integrin alpha-5, CD49 antigen-like family member E, Fibronectin receptor subunit alpha, Integrin alpha-F, VLA-5, CD49e, Integrin alpha-5 heavy chain, Integrin alpha-5 light chain, ITGA5, FNRA |
| Target/Specificity | Human ITGA5 |
| Reconstitution & Storage | Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles. |
| Precautions | ITGA5/Integrin Alpha 5/CD49e Antibody (clone 10F6) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | ITGA5 |
|---|---|
| Synonyms | FNRA |
| Function | Integrin alpha-5/beta-1 (ITGA5:ITGB1) is a receptor for fibronectin and fibrinogen. It recognizes the sequence R-G-D in its ligands. ITGA5:ITGB1 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1 (PubMed:18635536, PubMed:25398877). ITGA5:ITGB1 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1 (PubMed:12807887, PubMed:17158881). ITGA5:ITGB1 is a receptor for IL1B and binding is essential for IL1B signaling (PubMed:29030430). |
| Cellular Location | Membrane; Single-pass type I membrane protein. Cell junction, focal adhesion. Cell surface |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Integrin alpha-5/beta-1 is a receptor for fibronectin and fibrinogen. It recognizes the sequence R-G-D in its ligands. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.
References
Argraves W.S.,et al.J. Cell Biol. 105:1183-1190(1987).
Birkenmeier T.M.,et al.J. Biol. Chem. 266:20544-20549(1991).
Fitzgerald L.A.,et al.Biochemistry 26:8158-8165(1987).
Argraves W.S.,et al.J. Biol. Chem. 261:12922-12924(1986).
Takada Y.,et al.Proc. Natl. Acad. Sci. U.S.A. 84:3239-3243(1987).
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