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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   MFN1 Antibody (N-Terminus)   

MFN1 Antibody (N-Terminus)

Rabbit Polyclonal Antibody

  • IHC - MFN1 Antibody (N-Terminus) ALS16437
    Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE)
  • WB - MFN1 Antibody (N-Terminus) ALS16437
    Western blot analysis of MFN1 in A431 cell lysate with MFN1 antibody at 1 ug/ml.
  • ICC - MFN1 Antibody (N-Terminus) ALS16437
    Immunocytochemistry of MFN1 in A431 cells with MFN1 antibody at 5 ug/mL.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q8IWA4
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 84kDa
Dilution ICC (5 µg/ml), IHC-P (5 µg/ml), WB (1-2 µg/ml)
Additional Information
Gene ID 55669
Other Names Mitofusin-1, 3.6.5.-, Fzo homolog, Transmembrane GTPase MFN1, MFN1
Target/Specificity MFN1 antibody is human, mouse and rat reactive. MFN1 antibody is predicted to not cross-react with MFN2.
Reconstitution & Storage Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles.
PrecautionsMFN1 Antibody (N-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name MFN1
Function Mitochondrial outer membrane GTPase that mediates mitochondrial clustering and fusion (PubMed:12475957, PubMed:12759376, PubMed:27920125, PubMed:28114303). Membrane clustering requires GTPase activity (PubMed:27920125). It may involve a major rearrangement of the coiled coil domains (PubMed:27920125, PubMed:28114303). Mitochondria are highly dynamic organelles, and their morphology is determined by the equilibrium between mitochondrial fusion and fission events (PubMed:12475957, PubMed:12759376). Overexpression induces the formation of mitochondrial networks (in vitro) (PubMed:12759376). Has low GTPase activity (PubMed:27920125, PubMed:28114303).
Cellular Location Mitochondrion outer membrane; Multi- pass membrane protein
Tissue Location Detected in kidney and heart (at protein level) (PubMed:12759376). Ubiquitous (PubMed:11950885, PubMed:12759376). Expressed at slightly higher level in kidney and heart (PubMed:12759376). Isoform 2 may be overexpressed in some tumors, such as lung cancers (PubMed:11751411)
Research Areas
Citations (0)

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Essential transmembrane GTPase, which mediates mitochondrial fusion. Fusion of mitochondria occurs in many cell types and constitutes an important step in mitochondria morphology, which is balanced between fusion and fission. MFN1 acts independently of the cytoskeleton. Overexpression induces the formation of mitochondrial networks.


Santel A.,et al.J. Cell Sci. 114:867-874(2001).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Muzny D.M.,et al.Nature 440:1194-1198(2006).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Hales K.G.,et al.Cell 90:121-129(1997).

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$ 425.00
Cat# ALS16437
Availability: 5 days
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