|Application ||WB, IHC-P, E|
|Calculated MW||49542 Da|
|Dilution||ELISA, IHC-P (10 µg/ml), WB|
|Other Names||TUFM, EF-TuMT, EF-Tu, EFTU, p43, COXPD4|
|Target/Specificity||Human EFTU / TUFM|
|Reconstitution & Storage||PBS, pH 7.4, 0.03% Proclin 300, 50% glycerol. Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles.|
|Precautions||Anti-EFTU / TUFM Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. Plays also a role in the regulation of autophagy and innate immunity. Recruits ATG5-ATG12 and NLRX1 at mitochondria and serves as a checkpoint of the RIG-I/DDX58-MAVS pathway. In turn, inhibits RLR-mediated type I interferon while promoting autophagy.|
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