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Anti-LRRC8A / LRRC8 Antibody (N-Terminus)
Rabbit Anti Human Polyclonal Antibody
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Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | Q8IWT6 |
| Predicted | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Calculated MW | 94199 Da |
| Dilution | ELISA, IHC-P (2.5 - 5 µg/ml), WB (1 - 2 µg/ml) |
| Gene ID | 56262 |
|---|---|
| Alias Symbol | LRRC8A |
| Other Names | LRRC8A, AGM5, LRRC8, KIAA1437 |
| Target/Specificity | LRRC8A antibody is human, mouse and rat reactive. |
| Reconstitution & Storage | PBS, 0.02% sodium azide. Store at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze thaw cycles. |
| Precautions | Anti-LRRC8A / LRRC8 Antibody (N-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | LRRC8A |
|---|---|
| Function | Essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes (PubMed:24725410, PubMed:24790029, PubMed:26530471, PubMed:26824658, PubMed:28193731, PubMed:29769723). The VRAC channel conducts iodide better than chloride and can also conduct organic osmolytes like taurine (PubMed:24725410, PubMed:24790029, PubMed:26530471, PubMed:26824658, PubMed:28193731). Mediates efflux of amino acids, such as aspartate and glutamate, in response to osmotic stress (PubMed:28193731). LRRC8A and LRRC8D are required for the uptake of the drug cisplatin (PubMed:26530471). Required for in vivo channel activity, together with at least one other family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E); channel characteristics depend on the precise subunit composition (PubMed:24790029, PubMed:26824658, PubMed:28193731). Can form functional channels by itself (in vitro) (PubMed:26824658). Involved in B-cell development: required for the pro-B cell to pre-B cell transition (PubMed:14660746). Also required for T-cell development (By similarity). |
| Cellular Location | Cell membrane; Multi- pass membrane protein Note=The leucine-rich repeat (LRR) domain is on the cytoplasmic side of the cell membrane. |
| Tissue Location | Expressed in brain, kidney, ovary, lung, liver, heart, and fetal brain and liver. Found at high levels in bone marrow; lower levels are detected in peripheral blood cells Expressed on T-cells as well as on B-lineage cells |
Research Areas
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$ 425.00
Cat# ALS17304
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