|Application ||WB, IHC-P, Flo|
|Calculated MW||103829 Da|
|Dilution||Flo, IHC-P (10 µg/ml), WB|
|Other Names||TLR3, CD283, Toll-like receptor 3, CD283 antigen, IIAE2|
|Reconstitution & Storage||PBS, 0.05% sodium azide. Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.|
|Precautions||Anti-TLR3 Antibody (aa180-385, clone ABM24E5) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR3 is a nucleotide-sensing TLR which is activated by double-stranded RNA, a sign of viral infection. Acts via the adapter TRIF/TICAM1, leading to NF-kappa-B activation, IRF3 nuclear translocation, cytokine secretion and the inflammatory response.|
|Cellular Location||Endoplasmic reticulum membrane; Single-pass type I membrane protein. Endosome membrane. Early endosome|
|Tissue Location||Expressed at high level in placenta and pancreas. Also detected in CD11c+ immature dendritic cells. Only expressed in dendritic cells and not in other leukocytes, including monocyte precursors. TLR3 is the TLR that is expressed most strongly in the brain, especially in astrocytes, glia, and neurons.|
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