|Application ||WB, IHC-P, E|
|Calculated MW||59572 Da|
|Dilution||ELISA, IHC-P (1:200), WB|
|Other Names||SLC1A3, EA6, EAAT-1, EAAT1, GLAST, GLAST1, GLAST-1, GLUT-1|
|Target/Specificity||EAAT1 antibody detects endogenous levels of EAAT1.|
|Reconstitution & Storage||PBS, pH 7.4, 150 mM sodium chloride, 0.02% sodium azide, 50% glycerol Store at -20°C.|
|Precautions||Anti-SLC1A3 / EAAT1 Antibody (aa492-541) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate (PubMed:7521911, PubMed:8123008, PubMed:20477940, PubMed:26690923, PubMed:28032905, PubMed:28424515). Functions as a symporter that transports one amino acid molecule together with two or three Na(+) ions and one proton, in parallel with the counter-transport of one K(+) ion (PubMed:20477940). Mediates Cl(-) flux that is not coupled to amino acid transport; this avoids the accumulation of negative charges due to aspartate and Na(+) symport (PubMed:20477940). Plays a redundant role in the rapid removal of released glutamate from the synaptic cleft, which is essential for terminating the postsynaptic action of glutamate (By similarity).|
|Cellular Location||Cell membrane; Multi- pass membrane protein|
|Tissue Location||Detected in brain (PubMed:8218410, PubMed:7521911, PubMed:8123008). Detected at very much lower levels in heart, lung, placenta and skeletal muscle (PubMed:7521911, PubMed:8123008). Highly expressed in cerebellum, but also found in frontal cortex, hippocampus and basal ganglia (PubMed:7521911).|
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