|Application ||WB, IHC-P, E|
|Calculated MW||57492 Da|
|Dilution||ELISA (1:10000), IHC-P (5 µg/ml), WB (1:500 - 1:2000)|
|Other Names||CLK4, CDC-like kinase 4|
|Target/Specificity||CLK4 Polyclonal Antibody detects endogenous levels of CLK4 protein.|
|Reconstitution & Storage||PBS, 0.5% BSA, 0.02% sodium azide, 50% glycerol. Store at -20°C. Avoid freeze/thaw cycles.|
|Precautions||Anti-CLK4 Antibody (aa70-150) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex and may be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing. Phosphorylates SRSF1 and SRSF3. Required for the regulation of alternative splicing of MAPT/TAU. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells.|
|Tissue Location||Expressed in liver, kidney, heart, muscle, brain and endothelial cells.|
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