|Application ||WB, IHC-P|
|Predicted||Human, Mouse, Rat, Rabbit|
|Calculated MW||261731 Da|
|Dilution||IHC-P (1:100), WB (1:500 - 1:1000)|
|Other Names||CACNA1E, BII, Brain calcium channel II, Cav2.3, CACNL1A6, Alpha 1e, CACH6, Cchra1|
|Target/Specificity||Recognizes endogenous levels of Cav2.3 protein.|
|Reconstitution & Storage||PBS, pH 7.3, 0.01% sodium azide, 30% glycerol. Store at -20°C. Aliquot to avoid freeze/thaw cycles.|
|Precautions||Anti-CACNA1E / Cav2.3 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1E gives rise to R-type calcium currents. R-type calcium channels belong to the 'high-voltage activated' (HVA) group and are blocked by nickel. They are however insensitive to dihydropyridines (DHP). Calcium channels containing alpha-1E subunit could be involved in the modulation of firing patterns of neurons which is important for information processing.|
|Cellular Location||Membrane; Multi-pass membrane protein.|
|Tissue Location||Expressed in neuronal tissues and in kidney.|
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