|Application ||WB, IHC-P, IF, E|
|Calculated MW||47173 Da|
|Dilution||ELISA (1:20000 - 1:60000), IF (1:100 - 1:500), IHC-P (5 µg/ml), WB (1 µg/ml)|
|Other Names||SDPR, Cavin-2, CAVIN2, PS-p68, SDR, Serum deprivation response|
|Target/Specificity||This antibody is specific towards Cavin 2 SDR.|
|Reconstitution & Storage||Immunoaffinity purified|
|Precautions||Anti-SDR / SDPR Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Plays an important role in caveolar biogenesis and morphology. Regulates caveolae morphology by inducing membrane curvature within caveolae (PubMed:19525939). Plays a role in caveola formation in a tissue-specific manner. Required for the formation of caveolae in the lung and fat endothelia but not in the heart endothelia. Negatively regulates the size or stability of CAVIN complexes in the lung endothelial cells. May play a role in targeting PRKCA to caveolae (By similarity).|
|Cellular Location||Cytoplasm, cytosol Membrane, caveola. Note=Localizes in the caveolae in a caveolin-dependent manner.|
|Tissue Location||Highly expressed in heart and lung, and expressed at lower levels in brain, kidney, liver, pancreas, placenta, and skeletal muscle.|
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