|Application ||WB, IHC-P, E|
|Predicted||Human, Mouse, Rat|
|Calculated MW||44702 Da|
|Dilution||ELISA, IHC-P (1:50), WB|
|Other Names||BMP2, BDA2, BMP-2, BMP-2A, BMP2A, Bone morphogenetic protein 2, Bone morphogenetic protein 2A|
|Target/Specificity||BMP-2 antibody detects endogenous levels of BMP-2.|
|Reconstitution & Storage||Immunoaffinity purified|
|Precautions||Anti-BMP2 Antibody (aa226-275) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Induces cartilage and bone formation (PubMed:3201241). Stimulates the differentiation of myoblasts into osteoblasts via the EIF2AK3-EIF2A- ATF4 pathway. BMP2 activation of EIF2AK3 stimulates phosphorylation of EIF2A which leads to increased expression of ATF4 which plays a central role in osteoblast differentiation. In addition stimulates TMEM119, which upregulates the expression of ATF4 (PubMed:24362451).|
|Tissue Location||Particularly abundant in lung, spleen and colon and in low but significant levels in heart, brain, placenta, liver, skeletal muscle, kidney, pancreas, prostate, ovary and small intestine|
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