|Application ||WB, IHC-P, ICC, E|
|Calculated MW||21429 Da|
|Dilution||ELISA, ICC (10 µg/ml), IHC-P (10 µg/ml), WB|
|Other Names||IL11, AGIF, Adipogenesis inhibitory factor, IL-11, Interleukin-11, Oprelvekin, Interleukin 11|
|Target/Specificity||IL-11 antibody is human specific. At least two isoforms of IL-11 are known to exist; this antibody will only detect the longest isoform of IL-11.|
|Reconstitution & Storage||Immunoaffinity purified|
|Precautions||Anti-IL11 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Cytokine that stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells and induces megakaryocyte maturation resulting in increased platelet production (PubMed:2145578). Also promotes the proliferation of hepatocytes in response to liver damage. Binding to its receptor formed by IL6ST and either IL11RA1 or IL11RA2 activates a signaling cascade that promotes cell proliferation (PubMed:12919066). Signaling leads to the activation of intracellular protein kinases and the phosphorylation of STAT3.|
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