|Application ||WB, IHC-P|
|Calculated MW||26414 Da|
|Dilution||IHC-P (10 µg/ml), WB (1:2000)|
|Other Names||ADIPOQ, Adiponectin, ADPN, ACDC, ADIPQTL1, APM-1, APM1, ACRP30, Gelatin-binding protein 28, GBP28, Gelatin-binding protein|
|Reconstitution & Storage||Immunoaffinity purified|
|Precautions||Anti-Adiponectin Antibody (aa19-244, clone 3D11) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||ACDC, ACRP30, APM1, GBP28|
|Function||Important adipokine involved in the control of fat metabolism and insulin sensitivity, with direct anti-diabetic, anti-atherogenic and anti-inflammatory activities. Stimulates AMPK phosphorylation and activation in the liver and the skeletal muscle, enhancing glucose utilization and fatty-acid combustion. Antagonizes TNF-alpha by negatively regulating its expression in various tissues such as liver and macrophages, and also by counteracting its effects. Inhibits endothelial NF-kappa-B signaling through a cAMP-dependent pathway. May play a role in cell growth, angiogenesis and tissue remodeling by binding and sequestering various growth factors with distinct binding affinities, depending on the type of complex, LMW, MMW or HMW.|
|Tissue Location||Synthesized exclusively by adipocytes and secreted into plasma|
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