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Anti-ARG1 / Arginase 1 Antibody (clone 4E6)
Mouse Anti Human Monoclonal Antibody
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- BACKGROUND
Application 
| WB, IHC-P, Flo |
|---|---|
| Primary Accession | P05089 |
| Predicted | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | IgG1 |
| Clone Names | 4E6 |
| Calculated MW | 34735 Da |
| Dilution | Flo (1:100), IHC-P (10 µg/ml), WB (1:1000 - 1:2000) |
| Gene ID | 383 |
|---|---|
| Alias Symbol | ARG1 |
| Other Names | ARG1, Arginase, liver, Arginase 1, Liver-type arginase, Liver arginase, Arginase-1, Type I arginase |
| Target/Specificity | Human ARG1 / Arginase 1 |
| Reconstitution & Storage | Immunoaffinity purified |
| Precautions | Anti-ARG1 / Arginase 1 Antibody (clone 4E6) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | ARG1 |
|---|---|
| Function | Key element of the urea cycle converting L-arginine to urea and L-ornithine, which is further metabolized into metabolites proline and polyamides that drive collagen synthesis and bioenergetic pathways critical for cell proliferation, respectively; the urea cycle takes place primarily in the liver and, to a lesser extent, in the kidneys. |
| Cellular Location | Cytoplasm. Cytoplasmic granule. Note=Localized in azurophil granules of neutrophils (PubMed:15546957) |
| Tissue Location | Within the immune system initially reported to be selectively expressed in granulocytes (polymorphonuclear leukocytes [PMNs]) (PubMed:15546957). Also detected in macrophages mycobacterial granulomas (PubMed:23749634). Expressed in group2 innate lymphoid cells (ILC2s) during lung disease (PubMed:27043409). |
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$ 425.00
Cat# ALS18274
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