|Application ||WB, IHC-P|
|Predicted||Human, Mouse, Rat|
|Calculated MW||99188 Da|
|Dilution||IHC-P (1:200), WB (1:500 - 1:1000)|
|Other Names||AR, Androgen receptor, Dihydrotestosterone receptor, DHTR, AIS, KD, NR3C4, HUMARA, SBMA, TFM, SMAX1, HYSP1|
|Target/Specificity||Human Androgen Receptor|
|Reconstitution & Storage||Immunoaffinity purified|
|Precautions||Anti-AR / Androgen Receptor Antibody (aa611-660) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins. Transcription activation is down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3.|
|Cellular Location||Nucleus. Cytoplasm. Note=Detected at the promoter of target genes (PubMed:25091737). Predominantly cytoplasmic in unligated form but translocates to the nucleus upon ligand- binding. Can also translocate to the nucleus in unligated form in the presence of RACK1.|
|Tissue Location||Isoform 2 is mainly expressed in heart and skeletal muscle (PubMed:15634333). Isoform 3 is expressed by basal and stromal cells of prostate (at protein level) (PubMed:19244107).|
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