|Application ||WB, IHC-P, E|
|Calculated MW||49736 Da|
|Dilution||ELISA, IHC-P (1:50), WB|
|Other Names||CASP5, CASP-5, Caspase 5, Caspase-5, ICE(rel)III, ICEREL-III, ICE(rel)-III, Ich-3, Protease TY, ICH3, Protease ICH-3, TY protease|
|Target/Specificity||Caspase 5 (p20,Cleaved-Asp121) Antibody detects endogenous levels of fragment of activated Caspase 5 resulting from cleavage adjacent to Asp121.|
|Reconstitution & Storage||Immunoaffinity purified|
|Precautions||Anti-CASP5 / Caspase 5 Antibody (aa102-151) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Mediator of programmed cell death (apoptosis). During non-canonical inflammasome activation, cuts CGAS and may play a role in the regulation of antiviral innate immune activation (PubMed:28314590).|
|Tissue Location||Expressed in barely detectable amounts in most tissues except brain, highest levels being found in lung, liver and skeletal muscle|
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