|Application ||WB, IHC-P|
|Predicted||Human, Mouse, Rat|
|Calculated MW||77101 Da|
|Dilution||IHC-P (1:100), WB (1:500 - 1:1000)|
|Other Names||KCNQ4, DFNA2A, DFNA2, KV7.4, KQT-like 4, Potassium channel KQT-like 4|
|Target/Specificity||Recognizes endogenous levels of Kv7.4 protein.|
|Reconstitution & Storage||Immunoaffinity purified|
|Precautions||Anti-KCNQ4 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Probably important in the regulation of neuronal excitability. May underlie a potassium current involved in regulating the excitability of sensory cells of the cochlea. KCNQ4 channels are blocked by linopirdin, XE991 and bepridil, whereas clofilium is without significant effect. Muscarinic agonist oxotremorine-M strongly suppress KCNQ4 current in CHO cells in which cloned KCNQ4 channels were coexpressed with M1 muscarinic receptors.|
|Cellular Location||Basal cell membrane; Multi-pass membrane protein. Note=Situated at the basal membrane of cochlear outer hair cells.|
|Tissue Location||Expressed in the outer, but not the inner, sensory hair cells of the cochlea. Slightly expressed in heart, brain and skeletal muscle|
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