|Application ||WB, IHC-P, IP|
|Predicted||Human, Mouse, Rat, Monkey|
|Calculated MW||47088 Da|
|Dilution||IHC-P (1:100), IP (1:10 - 1:100), WB (1:500 - 1:1000)|
|Other Names||AKAP5, A-kinase anchor protein 79 kDa, A-kinase anchor protein, 79kDa, A-kinase anchor protein 79, A-kinase anchor protein 5, AKAP-5, AKAP75, AKAP 79, AKAP79, H21|
|Target/Specificity||Recognizes endogenous levels of AKAP5 protein.|
|Reconstitution & Storage||Immunoaffinity purified|
|Precautions||Anti-AKAP5 / AKAP79 Antibody (N-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May anchor the PKA protein to cytoskeletal and/or organelle-associated proteins, targeting the signal carried by cAMP to specific intracellular effectors. Association with to the beta2-adrenergic receptor (beta2-AR) not only regulates beta2-AR signaling pathway, but also the activation by PKA by switching off the beta2-AR signaling cascade.|
|Cellular Location||Membrane; Lipid-anchor. Note=Associates with lipid rafts|
|Tissue Location||Predominantly in the cerebral cortex and the postsynaptic densities of the forebrain, and to a lesser extent in adrenal medulla, lung and anterior pituitary|
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