|Application ||WB, IHC-P, E|
|Calculated MW||17263 Da|
|Dilution||ELISA, IHC-P (7.5 µg/ml), WB|
|Other Names||BLOC1S1, BLOS1, BLOC-1 subunit 1, BLOC subunit 1, GCN5-like protein 1, GCN5L1, MICoA, MTA1-interacting coactivator, Protein RT14, RT14|
|Reconstitution & Storage||Caprylic acid and ammonium sulfate precipitation|
|Precautions||Anti-BLOC1S1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||BLOS1, GCN5L1, RT14|
|Function||Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension (PubMed:17182842). As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor (PubMed:25898167).|
|Cellular Location||Mitochondrion intermembrane space. Mitochondrion matrix. Cytoplasm, cytosol. Lysosome membrane|
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