|Application ||WB, IHC-P, IF|
|Predicted||Human, Mouse, Rat|
|Calculated MW||243631 Da|
|Dilution||IF, IHC-P (1:100), WB|
|Other Names||NOTCH3, CASIL, CADASIL, Notch 3, Notch (Drosophila) homolog 3, Notch homolog 3, Notch homolog 3 (Drosophila)|
|Reconstitution & Storage||Affinity purified|
|Precautions||Anti-NOTCH3 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination (PubMed:15350543). Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity).|
|Cellular Location||Cell membrane; Single-pass type I membrane protein|
|Tissue Location||Ubiquitously expressed in fetal and adult tissues|
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