|Application ||WB, IHC-P|
|Predicted||Human, Mouse, Rat|
|Calculated MW||43573 Da|
|Dilution||IHC-P (1:100), WB|
|Other Names||SIRT3, HSIRT3, Sir2-like 3, SIR2-like protein 3, SIR2L3, Sirtuin 3, Sirtuin type 3|
|Target/Specificity||Human SIRT3 / Sirtuin 3|
|Reconstitution & Storage||Affinity purified|
|Precautions||Anti-SIRT3 / Sirtuin 3 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||NAD-dependent protein deacetylase (PubMed:12186850, PubMed:12374852, PubMed:16788062, PubMed:18680753, PubMed:18794531, PubMed:23283301, PubMed:24121500, PubMed:24252090, PubMed:19535340). Activates or deactivates mitochondrial target proteins by deacetylating key lysine residues (PubMed:12186850, PubMed:12374852, PubMed:16788062, PubMed:18680753, PubMed:18794531, PubMed:23283301, PubMed:24121500, PubMed:24252090). Known targets include ACSS1, IDH, GDH, SOD2, PDHA1, LCAD, SDHA and the ATP synthase subunit ATP5O (PubMed:16788062, PubMed:18680753, PubMed:24121500, PubMed:24252090, PubMed:19535340). Contributes to the regulation of the cellular energy metabolism (PubMed:24252090). Important for regulating tissue-specific ATP levels (PubMed:18794531). In response to metabolic stress, deacetylates transcription factor FOXO3 and recruits FOXO3 and mitochondrial RNA polymerase POLRMT to mtDNA to promote mtDNA transcription (PubMed:23283301).|
|Cellular Location||Mitochondrion matrix|
|Tissue Location||Widely expressed.|
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