Purified Mouse Monoclonal Antibody (Mab)
|Application ||WB, E|
|Calculated MW||98314 Da|
|Other Names||Proto-oncogene vav, VAV1, VAV|
|Target/Specificity||This VAV1 antibody is generated from a mouse immunized with a recombinant protein of human VAV1.|
|Format||Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||VAV1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Couples tyrosine kinase signals with the activation of the Rho/Rac GTPases, thus leading to cell differentiation and/or proliferation.|
|Tissue Location||Widely expressed in hematopoietic cells but not in other cell types|
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Provided below are standard protocols that you may find useful for product applications.
Couples tyrosine kinase signals with the activation of the Rho/Rac GTPases, thus leading to cell differentiation and/or proliferation.
Coppola J.,et al.Cell Growth Differ. 2:95-105(1991).
Denkinger D.J.,et al.Biochim. Biophys. Acta 1491:253-262(2000).
Grimwood J.,et al.Nature 428:529-535(2004).
Katzav S.,et al.Mol. Cell. Biol. 11:1912-1920(1991).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
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