Purified Mouse Monoclonal Antibody (Mab)
|Application ||WB, E|
|Calculated MW||23400 Da|
|Other Names||Ras-related protein R-Ras2, Ras-like protein TC21, Teratocarcinoma oncogene, RRAS2, TC21|
|Target/Specificity||This RRAS2 antibody is generated from a mouse immunized with a recombinant protein of human RRAS2.|
|Format||Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||RRAS2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||It is a plasma membrane-associated GTP-binding protein with GTPase activity. Might transduce growth inhibitory signals across the cell membrane, exerting its effect through an effector shared with the Ras proteins but in an antagonistic fashion.|
|Cellular Location||Cell membrane; Lipid-anchor; Cytoplasmic side. Note=Inner surface of plasma membrane possibly with attachment requiring acylation of the C-terminal cysteine (By similarity with RAS)|
|Tissue Location||Ubiquitously present in all tissues examined, with the highest levels in heart, placenta, and skeletal muscle Moderate levels in lung and liver; low levels in brain, kidney, and pancreas.|
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Provided below are standard protocols that you may find useful for product applications.
It is a plasma membrane-associated GTP-binding protein with GTPase activity. Might transduce growth inhibitory signals across the cell membrane, exerting its effect through an effector shared with the Ras proteins but in an antagonistic fashion.
Drivas G.T.,et al.Mol. Cell. Biol. 10:1793-1798(1990).
Chan A.M.-L.,et al.Proc. Natl. Acad. Sci. U.S.A. 91:7558-7562(1994).
Puhl H.L. III,et al.Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Taylor T.D.,et al.Nature 440:497-500(2006).
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