|Application ||IHC-P, FC, WB, E|
|Calculated MW||285215 Da|
|Other Names||Unconventional myosin-XVIIIb, MYO18B|
|Target/Specificity||This MYO18B antibody is generated from a mouse immunized with recombinant protein from human MYO18B.|
|Format||Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||MYO18B Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May be involved in intracellular trafficking of the muscle cell when in the cytoplasm, whereas entering the nucleus, may be involved in the regulation of muscle specific genes. May play a role in the control of tumor development and progression; restored MYO18B expression in lung cancer cells suppresses anchorage-independent growth.|
|Cellular Location||Cytoplasm. Nucleus. Cytoplasm, myofibril, sarcomere. Note=Punctate pattern in undifferentiated myoblasts Nuclear, on primary cardiomyocytes and adult muscle. A partial sarcomeric location was found in some cardiomyocytes|
|Tissue Location||Selectively expressed in cardiac and skeletal muscles. Weakly expressed in testis, pancreas, placenta, prostate, lung and thymus|
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Provided below are standard protocols that you may find useful for product applications.
May be involved in intracellular trafficking of the muscle cell when in the cytoplasm, whereas entering the nucleus, may be involved in the regulation of muscle specific genes. May play a role in the control of tumor development and progression; restored MYO18B expression in lung cancer cells suppresses anchorage-independent growth.
Nishioka M.,et al.Proc. Natl. Acad. Sci. U.S.A. 99:12269-12274(2002).
Salamon M.,et al.J. Mol. Biol. 326:137-149(2003).
Gu Y.,et al.Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases.
Dunham I.,et al.Nature 402:489-495(1999).
Stanchi F.,et al.Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases.
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