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>   home   >   Products   >   Primary Antibodies   >   KSHV K8a Antibody   

KSHV K8a Antibody

Purified Mouse Monoclonal Antibody

  • WB - KSHV K8a Antibody AO1015a
    Figure 1: Western blot analysis using KSHV K8α mouse mAb against BCBL-1 (1) and TPA induced BCBL-1 (2) cell lysate.
  • IHC - KSHV K8a Antibody AO1015a
    Figure 2: Immunocytochemistry analysis of TPA induced BCBL-1 cells (A) and uninduced BCBL-1 cells (B) using KSHV K8α mouse mAb with AEC staining.
  •  - KSHV K8a Antibody AO1015a
    Figure 2: Immunocytochemistry analysis of TPA induced BCBL-1 cells(A) and uninduced BCBL-1 cells(B) using anti-KSHV K8α monoclonal antibody with AEC staining.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q2HR82
Host Mouse
Clonality Monoclonal
Clone Names 8C12G10G1
Isotype IgG2a
Calculated MW 31574 Da
Description Kaposi's sarcoma-associated herpesvirus (KSHV) belongs to the gamma-(2)-herpesvirus subfamily and has been closely linked to the Kaposi’s sarcoma, primary effusion lymphoma (PEL) and multicentric Castleman’s disease. The genome of KSHV is 165-170 kb and contains at least 88 open reading frames. KSHV K8 and K8.1 open reading frames are juxtaposed and span from nucleotide (nt) 74850 to 76695 of the virus genome. A K8 pre-mRNA overlaps the entire K8.1 coding region, and alternative splicing of KSHV K8 and K8.1 pre-mRNAs each produces three isoforms (α, β, and γ) of the mRNAs.
Immunogen Purified recombinant fragment of KSHV K8α expressed in E. Coli.
Formulation Ascitic fluid containing 0.03% sodium azide.
Additional Information
Gene ID 4961462
Other Names E3 SUMO-protein ligase K-bZIP, 6.3.2.-, K8
Dilution WB~~1/500 - 1/2000
IHC~~1/200 - 1/1000
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsKSHV K8a Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name K8
Function Plays a role in viral gene regulation and seems to be essential for KSHV reactivation. Disrupts host G1 cell cycle control thus allowing viral transcription and translation to proceed at the early stages of infection. Catalyzes its own SUMO modification as well as that of its interacting partners such as host TP53 AND RB1.
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1. James J et al. Proc. Natl. Acad. Sci Vol. 1996. 93, pp. 14862-14867.

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$ 385.00
Cat# AO1015a
Availability: 7-10 days
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