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KSHV ORF45 Antibody

Purified Mouse Monoclonal Antibody

  • WB - KSHV ORF45 Antibody AO1016a
    Figure 1: Western blot analysis using KSHV ORF45 mouse mAb against KSHV ORF45 recombinant protein.
  • IHC - KSHV ORF45 Antibody AO1016a
    Figure 2: Immunocytochemistry analysis of TPA induced BCBL-1 cells (A) and uninduced BCBL-1 cells (B) using KSHV ORF45 mouse mAb with AEC staining.
  •  - KSHV ORF45 Antibody AO1016a
    Figure 2: Immunocytochemistry analysis of TPA induced BCBL-1 cells(A) and uninduced BCBL-1 cells(B) using anti-KSHV ORF45 monoclonal antibody with AEC staining.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession F5HDE4
Host Mouse
Clonality Monoclonal
Clone Names 2D4A5
Isotype IgG1
Calculated MW 43327 Da
Description Kaposi's sarcoma-associated herpesvirus (KSHV) belongs to the gamma-(2)-herpesvirus subfamily and has been closely linked to the Kaposi’s sarcoma, primary effusion lymphoma (PEL) and multicentric Castleman’s disease. The genome of KSHV is 165-170 kb and contains at least 88 open reading frames. ORF45 protein encoded by an immediate-early gene in the KSHV genome is characterized as a phosphorylated protein, and it is localized in the cytoplasm of infected cells. Studies have shown that ORF45 Protein interacted with cellular IRF-7 and blocked virus-mediated phosphorylation and nuclear translocation of IRF-7. In consequence, ORF45 efficiently inhibited virus-induced production of type I IFN. Zhu et al (2003) reported that the ORF45 Protein was associated with purified virions
Immunogen Purified recombinant fragment of KSHV ORF45 expressed in E. Coli.
Formulation Ascitic fluid containing 0.03% sodium azide.
Additional Information
Gene ID 4961474
Other Names Protein ORF45, ORF45
Dilution WB~~1/500 - 1/2000
IHC~~1/200 - 1/1000
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsKSHV ORF45 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ORF45
Function Prevents the establishment of cellular antiviral state by blocking virus-induced phosphorylation and activation of host interferon regulatory factor 7/IRF7, a transcription factor critical for the induction of interferons alpha and beta. Mechanistically, ORF45 competes with the associated IRF7 and inhibits its phosphorylation by IKBKE or TBK1 by acting as an alternative substrate.
Cellular Location Virion tegument. Host cytoplasm. Host nucleus
Citations (0)

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1. Chang Y. et al. 1994. Science. 266:1865-1869. 2. Zhu FX. et al. 2002. PNAS. 99: 5573-5578. 3. Zhu FX. et al. J Virol. 2003. April (77): 4221-4230.

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$ 385.00
Cat# AO1016a
Availability: 7-10 days
Bulk Size
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