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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   Thioredoxin (TRX) Antibody   

Thioredoxin (TRX) Antibody

Purified Mouse Monoclonal Antibody

  • WB - Thioredoxin (TRX) Antibody AO1101a
    Figure 1: Western blot analysis using Trx mouse mAb against various fusion protein with Trx tag.
  • IHC - Thioredoxin (TRX) Antibody AO1101a
    Figure 2: Immunohistochemical analysis of paraffin-embedded human breast intraductal carcinama tissue(A) and breast infiltrating ductal carcinama tissue(B) showing membrane localization using HER-2 mouse mAb with DAB staining.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P10599
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 1H6H6
Isotype IgG1
Calculated MW 12kDa
Description Thioredoxin (TRX) is a small ubiquitous protein (MW12kDa) which is exist in a wide variety of prokaryotic and eukaryotic cells. Trx contains a redox active disulfide/dithiol group within the conserved Cys-Gly-Pro-Cys active site. This antibody is suitable for detecting fusion proteins which encode a Trx-Tag by immunoblotting and immunoprecipitation. The Monoclonal Antibody can detect a little Trx-Tag fusion proteins with negligible cross-reactivity with bacterial, insect, or mammalian lysates.
Immunogen Purified recombinant fusion protein with Thioredoxin (TRX) tag.
Formulation Ascitic fluid containing 0.03% sodium azide.
Additional Information
Gene ID 7295
Dilution WB~~1/500 - 1/2000
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsThioredoxin (TRX) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name TXN
Synonyms TRDX, TRX, TRX1
Function Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions. Plays a role in the reversible S-nitrosylation of cysteine residues in target proteins, and thereby contributes to the response to intracellular nitric oxide. Nitrosylates the active site Cys of CASP3 in response to nitric oxide (NO), and thereby inhibits caspase-3 activity. Induces the FOS/JUN AP-1 DNA-binding activity in ionizing radiation (IR) cells through its oxidation/reduction status and stimulates AP-1 transcriptional activity.
Cellular Location Nucleus. Cytoplasm Secreted. Note=Translocates from the cytoplasm into the nucleus after phorbol 12-myristate 13-acetate induction (PMA) (PubMed:9108029). Predominantly in the cytoplasm in non irradiated cells (PubMed:11118054). Radiation induces translocation of TRX from the cytoplasm to the nucleus (PubMed:11118054). Secreted by a leaderless secretory pathway (PubMed:1332947).
Research Areas
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1. Holmgen, A. et al., Annu. Rev. Biochem. 54, 237-271 (1985). 2. Wollman, E. E. et al., J. Biol. Chem. 263, 15506-15512 (1988). 3. Sasada, T. et al., J. Toxicol. Sci. 21, 285-287 (1996).

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$ 300.00
Cat# AO1101a
Availability: 7-10 days
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