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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   SORL1 Antibody   

SORL1 Antibody

Purified Mouse Monoclonal Antibody

  • WB - SORL1 Antibody AO1137a
    Figure 1: Western blot analysis using SORL1 mouse mAb against truncated SORL1 recombinant protein (1) and SORL1 (aa2159-2214)-hIgGFc transfected CHO-K1 cell lysate (2).
  • IHC - SORL1 Antibody AO1137a
    Figure 2: Immunohistochemical analysis of paraffin-embedded human ovary carcinoma (A), normal cerebrum tissues (B), breast infiltrating carcinoma (C) and breast infiltrating carcinoma (D), showing cytoplasmic localization using STYK1/NOK mouse mAb with DAB staining.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q92673
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 7D7B11
Isotype IgG1
Calculated MW 248426 Da
Description SORL1 (sortilin-related receptor, L A repeats containing) also known as sorting protein-related receptor containing LDLR class A (SorLA), is a Type I membrane protein that may be involved in cell-cell interaction. SorLA, a single transmembrane receptor, binds LDL and transports it into cells by endocytosis. SorLA is synthesized as a proreceptor which is processed to the mature form by a furin-like propeptidase. It can also bind to RAP (receptor-associated protein). SorLA is a multifunctional endocytis receptor important in lipoprotein and protease uptake. The N-terminal propeptide, which is removed, can be cleaved by furin or homologous proteases. Endogenous SorLA binds the neuropeptide head activator (HA) and is important for HA signaling and function. The gene encoding for the protein maps to chromosome 8p23.1. SorLA is expressed mainly in brain (cerebral cortex, cerebellum and the occipital pole), but can also be found in liver, spinal cord, kidney, testis and pancreas.
Immunogen Purified recombinant fragment of SORL1 (aa2159-2214) expressed in E. Coli.
Formulation Ascitic fluid containing 0.03% sodium azide.
Additional Information
Gene ID 6653
Other Names Sortilin-related receptor, Low-density lipoprotein receptor relative with 11 ligand-binding repeats, LDLR relative with 11 ligand-binding repeats, LR11, SorLA-1, Sorting protein-related receptor containing LDLR class A repeats, SorLA, SORL1, C11orf32
Dilution WB~~1/500 - 1/2000
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsSORL1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SORL1
Synonyms C11orf32
Function Likely to be a multifunctional endocytic receptor, that may be implicated in the uptake of lipoproteins and of proteases. Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. Binds the receptor- associated protein (RAP). Could play a role in cell-cell interaction. Involved in APP trafficking to and from the Golgi apparatus. It probably acts as a sorting receptor that protects APP from trafficking to late endosome and from processing into amyloid beta, thereby reducing the burden of amyloidogenic peptide formation. Involved in the regulation of smooth muscle cells migration, probably through PLAUR binding and decreased internalization.
Cellular Location Membrane; Single-pass type I membrane protein. Golgi apparatus. Endosome Secreted
Tissue Location Expressed mainly in brain, where it is most abundant in the cerebellum, cerebral cortex and the occipital pole; low expression in the putamen and the thalamus. Expression is significantly reduced in the frontal cortex of patients suffering from Alzheimer disease. According to PubMed:9157966, found in spinal cord, testis, liver, kidney and pancreas with detectable levels in placenta, lung and heart. According to PubMed:8940146, expressed in the prostate, ovary, thyroid and spleen, but not found in kidney, liver, lung, skeletal muscle, bone marrow and adrenals.
Research Areas
Citations (0)

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1. Scherzer CR. Offe K. Gearing M. et al. Arch Neurol. 2004, Aug, 61(8):1200-5. 2. Gabrielsson BG. Olofsson LE. Sjogren A. et al. Obes Res. 2005, Apr, 13(4):649-52. 3. Shah S. Yu G. Mol Interv. 2006, Apr, 6(2):74-6, 58. Review.

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$ 385.00
Cat# AO1137a
Availability: 7-10 days
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