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IGFBP2 Antibody

Purified Mouse Monoclonal Antibody

  • WB - IGFBP2 Antibody AO1169a
    Figure 1: Western blot analysis using IGFBP2 mouse mAb against truncated IGFBP2-His recombinant protein (1) and truncated IGFBP2 (aa40-328)-hIgGFc transfected CHO-K1 cell lysate (2).
  • IHC - IGFBP2 Antibody AO1169a
    Figure 2: Immunohistochemical analysis of paraffin-embedded human lung cancer (A), recturn(B), prostate (C), colon cancer (D) showing cytoplasmic localization using IGFBP2 mouse mAb with DAB staining.
  • ICC - IGFBP2 Antibody AO1169a
    Figure 2: Immunofluorescence staining of methanol-fixed A431 (left) and Hela (right) cells showing cytoplasmic and membrane localization.
  • IF - IGFBP2 Antibody AO1169a
    Figure 2: Immunofluorescence staining of methanol-fixed A431(left) and Hela(right) cells showing cytoplasmic and membrane localization.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P18065
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 1F6F6
Isotype IgG1
Calculated MW 34814 Da
Description IGFBP2: insulin-like growth factor binding protein 2. IGFBP2 is a member of the ISGBP family which bind various IGFs. IGFBP2 is overexpressed in a wide spectrum of other cancers, including glioma, prostate cancer, synovial sarcoma, neuroblastoma, colon cancer, adrenocortical cancer, lung cancer, Wilms' tumor, and hepatoblastoma. The overexpression of IGFBP2 also correlates with the aggressiveness of some tumors. IGFBP2 activates the expression of matrix metalloprotease 2, which contributes to cell invasiveness.
Immunogen Purified recombinant fragment of protein IGFBP2 (aa180-328) expressed in E. Coli.
Formulation Ascitic fluid containing 0.03% sodium azide.
Additional Information
Gene ID 3485
Other Names Insulin-like growth factor-binding protein 2, IBP-2, IGF-binding protein 2, IGFBP-2, IGFBP2, BP2, IBP2
Dilution WB~~1/500 - 1/2000
IHC~~1/200 - 1/1000
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsIGFBP2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms BP2, IBP2
Function Inhibits IGF-mediated growth and developmental rates. IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.
Cellular Location Secreted.
Research Areas
Citations (0)

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1. Oncol Rep. 2005 Feb;13(2):341-5. 2. Prostate. 2005 Jun 15;64(1):9-19. 3. Bone. 2005 Dec;37(6):741-50.

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$ 385.00
Cat# AO1169a
Availability: 7-10 days
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