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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   Tyro3 Antibody   

Tyro3 Antibody

Purified Mouse Monoclonal Antibody

  • IF - Tyro3 Antibody AO1173a
    Figure 2: Immunofluorescence analysis of Hela (Left) and MCF-7 (Right) cells using Tyro3 mouse mAb (green).
  • WB - Tyro3 Antibody AO1173a
    Figure 1: Western blot analysis using PYK2 mouse mAb against Raji (1), PMA induced THP-1 (2), Jurkat (3) and Ramos (4) cell lysate.
  • IHC - Tyro3 Antibody AO1173a
    Figure 2: Immunohistochemical analysis of paraffin-embedded human Tonsil tissues using PYK2 mouse mAb.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q06418
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 6D6F10
Isotype IgG1
Calculated MW 96905 Da
Description Tyro3 (also known as Sky and Rse), with 890-amino acid protein (about 98kDa), belongs to the Axl/Tyro3 family of receptor tyrosine kinases, which also includes Axl and Mer.Gas6 (growth arrest-specific gene-6) is a ligand for all members of the Axl family and they play essential roles in spermatogenesis, immunoregulation, and phagocytosis.Tyro3 was expressed at high levels during postnatal development and in the adult in the cortex.Tyro3 and Gas6 have neurotrophic roles in the nervous system.In addition, the signalling interactions of Axl and Tyro3 may play roles in tumourigenesis, inflammation as well as other cell proliferative diseases.
Immunogen Purified recombinant fragment of Tyro3 (aa138-321) expressed in E. Coli.
Formulation Ascitic fluid containing 0.03% sodium azide.
Additional Information
Gene ID 7301
Other Names Tyrosine-protein kinase receptor TYRO3,, Tyrosine-protein kinase BYK, Tyrosine-protein kinase DTK, Tyrosine-protein kinase RSE, Tyrosine-protein kinase SKY, Tyrosine-protein kinase TIF, TYRO3, BYK, DTK, RSE, SKY, TIF
Dilution IF~~1/200 - 1/1000
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsTyro3 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name TYRO3
Synonyms BYK, DTK, RSE, SKY, TIF
Function Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including TULP1 or GAS6. Regulates many physiological processes including cell survival, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of TYRO3 on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with PIK3R1 and thereby enhances PI3-kinase activity. Activates the AKT survival pathway, including nuclear translocation of NF-kappa-B and up-regulation of transcription of NF-kappa-B-regulated genes. TYRO3 signaling plays a role in various processes such as neuron protection from excitotoxic injury, platelet aggregation and cytoskeleton reorganization. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3.
Cellular Location Cell membrane; Single-pass type I membrane protein
Tissue Location Abundant in the brain and lower levels in other tissues
Research Areas
Citations (0)

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1. Christoph Heiring, Bjon Dahlbok, and Yves A. Muller. J. Biol. Chem Feb 2004; 279: 6952 - 6958. 2. Sassan Hafizi, Anna Gustafsson, Jonas Stenhoff. Int J Biochem Cell Biol. 2005 Nov;37(11):2344-56.

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$ 325.00
Cat# AO1173a
Availability: 7-10 days
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