|Application ||IHC, E|
|Description||MPS1, also known as RPS27. It is a ribosomal protein. Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. MPS1 is a component of the 40S subunit. The protein belongs to the S27E family of ribosomal proteins. It contains a C4-type zinc finger domain that can bind to zinc. The encoded protein has been shown to be able to bind to nucleic acid. It is located in the cytoplasm as a ribosomal component, but it has also been detected in the nucleus. Studies in rat indicate that ribosomal protein S27 is located near ribosomal protein S18 in the 40S subunit and is covalently linked to translation initiation factor eIF3. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.|
|Immunogen||Purified recombinant fragment of MPS1 expressed in E. Coli.|
|Formulation||Ascitic fluid containing 0.03% sodium azide.|
|Other Names||40S ribosomal protein S27, Metallopan-stimulin 1, MPS-1, RPS27, MPS1|
|Dilution||IHC~~1/200 - 1/1000|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||MPS1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Component of the small ribosomal subunit (PubMed:8706699). Required for proper rRNA processing and maturation of 18S rRNAs (PubMed:25424902).|
|Tissue Location||Expressed in a wide variety of actively proliferating cells and tumor tissues|
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1. Biochem Cell Biol. 1995 Nov-Dec;73(11-12):933-47. 2. Mol Biol Cell. 2003 Apr;14(4):1638-51. 3. Cell. 2008 Jan 25;132(2):233-46.
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