|Application ||WB, FC, E|
|Description||The protein encoded by this gene is an activator of MAP3K7/TAK1, which is required for for the IL-1 induced activation of nuclear factor kappaB and MAPK8/JNK. This protein forms a kinase complex with TRAF6, MAP3K7 and TAB1, thus serves as an adaptor linking MAP3K7 and TRAF6. This protein, TAB1, and MAP3K7 also participate in the signal transduction induced by TNFSF11/RANKl through the activation of the receptor activator of NF-kappB (TNFRSF11A/RANK), which may regulate the development and function of osteoclasts.|
|Immunogen||Purified recombinant fragment of human TAB2 expressed in E. Coli.|
|Formulation||Ascitic fluid containing 0.03% sodium azide.|
|Other Names||TGF-beta-activated kinase 1 and MAP3K7-binding protein 2, Mitogen-activated protein kinase kinase kinase 7-interacting protein 2, TAK1-binding protein 2, TAB-2, TGF-beta-activated kinase 1-binding protein 2, TAB2, KIAA0733, MAP3K7IP2|
|Dilution||WB~~1/500 - 1/2000|
FC~~1/200 - 1/400
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||TAB2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Adapter linking MAP3K7/TAK1 and TRAF6. Promotes MAP3K7 activation in the IL1 signaling pathway. The binding of 'Lys-63'- linked polyubiquitin chains to TAB2 promotes autophosphorylation of MAP3K7 at 'Thr-187'. Involved in heart development.|
|Cellular Location||Membrane; Peripheral membrane protein Cytoplasm, cytosol. Note=Following IL1 stimulation, translocation occurs from the membrane to cytosol|
|Tissue Location||Widely expressed. In the embryo, expressed in the ventricular trabeculae, endothelial cells of the conotruncal cushions of the outflow tract and in the endothelial cells lining the developing aortic valves.|
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1. J Clin Endocrinol Metab. 2006 Mar;91(3):1056-61. 2. Sci STKE. 2006 Oct 17;2006(357):re13. 3. Am J Hum Genet. 2010 Jun 11;86(6):839-49.
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