|Application ||WB, FC, E|
|Description||This gene encodes one of the numerous actin-binding proteins which regulate the actin cytoskeleton. This protein binds F-actin, and also interacts with 5-lipoxygenase, which is the first committed enzyme in leukotriene biosynthesis. Although this gene has been reported to map to chromosome 17 in the Smith-Magenis syndrome region, the best alignments for this gene are to chromosome 16. The Smith-Magenis syndrome region is the site of two related pseudogenes.|
|Immunogen||Purified recombinant fragment of human COTL1 expressed in E. Coli. |
|Formulation||Purified antibody in PBS with 0.05% sodium azide|
|Other Names||Coactosin-like protein, COTL1, CLP|
WB~~1/500 - 1/2000
FC~~1/200 - 1/400
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||COTL1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Binds to F-actin in a calcium-independent manner. Has no direct effect on actin depolymerization. Acts as a chaperone for ALOX5 (5LO), influencing both its stability and activity in leukotrienes synthesis.|
|Cellular Location||Cytoplasm. Cytoplasm, cytoskeleton. Nucleus|
|Tissue Location||Widely expressed with highest levels in placenta, lung, kidney and peripheral blood leukocytes and lower levels in brain, liver and pancreas|
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1. Biochem J. 2009 Dec 14;425(1):265-74. 2. Exp Mol Med. 2009 May 31;41(5):354-61.
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