|Application ||WB, FC, E|
|Isotype||4A11F8 IgG2b/4A11G2 IgG1|
|Description||This gene is a homolog of the Drosophila delta gene. The delta gene family encodes Notch ligands that are characterized by a DSL domain, EGF repeats, and a transmembrane domain.|
|Immunogen||Purified recombinant fragment of human DLL4 expressed in E. Coli. |
|Formulation||Purified antibody in PBS with 0.05% sodium azide|
|Other Names||Delta-like protein 4, Drosophila Delta homolog 4, Delta4, DLL4|
WB~~1/500 - 1/2000
FC~~1/200 - 1/400
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||DLL4 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Involved in the Notch signaling pathway as Notch ligand (PubMed:11134954). Activates NOTCH1 and NOTCH4. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting (PubMed:20616313). Essential for retinal progenitor proliferation. Required for suppressing rod fates in late retinal progenitors as well as for proper generation of other retinal cell types (By similarity). During spinal cord neurogenesis, inhibits V2a interneuron fate (PubMed:17728344).|
|Cellular Location||Cell membrane; Single-pass type I membrane protein|
|Tissue Location||Expressed in vascular endothelium.|
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