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FZD5 Antibody

Purified Mouse Monoclonal Antibody

  • E - FZD5 Antibody AO1760a

    Black line: Control Antigen (100 ng);
    Purple line: Antigen(10ng);
    Blue line: Antigen (50 ng);
    Red line: Antigen (100 ng);

  • WB - FZD5 Antibody AO1760a
    Figure 1: Western blot analysis using FZD5 mAb against human FZD5 recombinant protein. (Expected MW is 32.5 kDa)
  • WB - FZD5 Antibody AO1760a
    Figure 2: Western blot analysis using FZD5 mouse mAb against A549 (1), and PC-3 (2) cell lysate.
  • FC - FZD5 Antibody AO1760a
    Figure 3: Flow cytometric analysis of HepG2 cells using FZD5 mouse mAb (green) and negative control (red).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q13467
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 2D12
Isotype IgG1
Calculated MW 64.5kDa
Description Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD5 protein is believed to be the receptor for the Wnt5A ligand.
Immunogen Purified recombinant fragment of human FZD5 (AA:151-217) expressed in E. Coli.
Formulation Purified antibody in PBS with 0.05% sodium azide
Additional Information
Gene ID 7855
Other Names Frizzled-5, Fz-5, hFz5, FzE5, FZD5, C2orf31
Dilution E~~1/10000
WB~~1/500 - 1/2000
FC~~1/200 - 1/400
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsFZD5 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name FZD5
Synonyms C2orf31
Function Receptor for Wnt proteins (PubMed:9054360, PubMed:10097073, PubMed:20530549). Can activate WNT2, WNT10B, WNT5A, but not WNT2B or WNT4 (in vitro); the in vivo situation may be different since not all of these are known to be coexpressed (By similarity). In neurons, activation of WNT7A promotes formation of synapses (PubMed:20530549). Functions in the canonical Wnt/beta-catenin signaling pathway. The canonical Wnt/beta-catenin signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes (By similarity). A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues (Probable). Plays a role in yolk sac angiogenesis and in placental vascularization (By similarity).
Cellular Location Cell membrane {ECO:0000250|UniProtKB:Q8CHL0}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q8CHL0}. Golgi apparatus membrane {ECO:0000250|UniProtKB:Q9EQD0}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9EQD0}. Cell junction, synapse {ECO:0000250|UniProtKB:Q8CHL0}. Perikaryon {ECO:0000250|UniProtKB:Q8CHL0}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q8CHL0}. Cell projection, axon {ECO:0000250|UniProtKB:Q8CHL0}. Note=Localized at the plasma membrane and also found at the Golgi {ECO:0000250|UniProtKB:Q9EQD0}
Research Areas
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1.J Biol Chem. 2009 Sep 25;284(39):26716-24.2.Int J Oncol. 2007 Mar;30(3):751-5.

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$ 385.00
Cat# AO1760a
Availability: 7-10 days
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