|Application ||WB, FC, E|
|Description||SPLUNC2 is one member of PLUNC family, the gene undergoes alternative splicing using two 5' non-coding exons, suggesting that the gene is regulated by alternative promoters.multiple SPLUNC2 isoforms are found in the oral cavity and suggest that these proteins may be differentially regulated in distinct tissues where they may function in the innate immune response. Mucin plugs, mucous and intermediate cells of mucoepidermoid carcinomas were positive for LPLUNC1 and SPLUNC2, but areas composed of epidermoid and clear cells were negative for all PLUNCs. Papillary cystadenocarcinoma was positive for all PLUNCs.|
|Immunogen||Purified recombinant fragment of human Splunc2 (AA: 16-250) expressed in E. Coli.|
|Formulation||Purified antibody in PBS with 0.05% sodium azide|
|Other Names||BPI fold-containing family A member 2, Parotid secretory protein, PSP, Short palate, lung and nasal epithelium carcinoma-associated protein 2, BPIFA2, C20orf70, SPLUNC2|
WB~~1/500 - 1/2000
FC~~1/200 - 1/400
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||human Splunc2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Has strong antibacterial activity against P. aeruginosa.|
|Tissue Location||Detected in submandibular gland. Secreted into saliva.|
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1.Histochem Cell Biol. 2009 Sep;132(3):339-49. 2.Oral Dis. 2008 Oct;14(7):613-9.
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