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>   home   >   Products   >   Primary Antibodies   >   Cell Biology   >   KBTBD8 Antibody   

KBTBD8 Antibody

Purified Mouse Monoclonal Antibody

  • E - KBTBD8 Antibody AO2031a

    Figure 1:Black line: Control Antigen (100 ng);
    Purple line: Antigen(10ng);
    Blue line: Antigen (50 ng);
    Red line: Antigen (100 ng);

  • WB - KBTBD8 Antibody AO2031a

    Figure 2:Western blot analysis using KBTBD8 mAb against human KBTBD8 (AA: 264-464) recombinant protein. (Expected MW is 48.7 kDa)

  • WB - KBTBD8 Antibody AO2031a

    Figure 3:Western blot analysis using KBTBD8 mAb =against HEK293 (1) and KBTBD8 (AA: 264-464)-hIgGFc transfected HEK293 (2) cell lysate.

  • WB - KBTBD8 Antibody AO2031a

    Figure 4:Western blot analysis using KBTBD8 mouse mAb against A431 (1), Jurkat (2), Hela (3), K562 (4), and HEK293 (5) cell lysate.

  • FC - KBTBD8 Antibody AO2031a

    Figure 5:Flow cytometric analysis of A431 cells using KBTBD8 mouse mAb (green) and negative control (red).

Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q8NFY9
Reactivity Human
Host Mouse
Clonality Monoclonal
Clone Names 7G8A6
Isotype IgG1
Calculated MW 68.8kDa
Description KBTBD8 (kelch repeat and BTB (POZ) domain containing 8) is a protein-coding gene. An important paralog of this gene is KLHL21.
Immunogen Purified recombinant fragment of human KBTBD8 (AA: 264-464) expressed in E. Coli.
Formulation Purified antibody in PBS with 0.05% sodium azide
Additional Information
Gene ID 84541
Other Names Kelch repeat and BTB domain-containing protein 8, T-cell activation kelch repeat protein, TA-KRP, KBTBD8, KIAA1842, TAKRP
Dilution E~~1/10000
WB~~1/500 - 1/2000
FC~~1/200 - 1/400
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsKBTBD8 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms KIAA1842, TAKRP
Function Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of neural crest specification (PubMed:26399832). The BCR(KBTBD8) complex acts by mediating monoubiquitination of NOLC1 and TCOF1: monoubiquitination promotes the formation of a NOLC1-TCOF1 complex that acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification (PubMed:26399832).
Cellular Location Cytoplasm, cytoskeleton, spindle. Golgi apparatus. Note=Translocates to the spindle apparatus during mitosis.
Research Areas
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Cell Div. 2013 Apr 11;8(1):3.J Hum Genet. 2010 Jan;55(1):27-31.

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$ 385.00
Cat# AO2031a
Availability: 7-10 days
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