|Application ||WB, IHC, FC, E|
|Description||CBX4 (chromobox homolog 4) is a protein-coding gene. Diseases associated with CBX4 include brain cancer. GO annotations related to this gene include chromatin binding and transcription corepressor activity. An important paralog of this gene is CBX8.|
|Immunogen||Purified recombinant fragment of human CBX4 (AA: 397-514) expressed in E. Coli.|
|Formulation||Purified antibody in PBS with 0.05% sodium azide|
|Other Names||E3 SUMO-protein ligase CBX4, 6.3.2.-, Chromobox protein homolog 4, Polycomb 2 homolog, Pc2, hPc2, CBX4|
WB~~1/500 - 1/2000
FC~~1/200 - 1/400
IHC~~1/200 - 1/1000
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CBX4 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||E3 SUMO-protein ligase which facilitates SUMO1 conjugation by UBE2I (PubMed:12679040). Involved in the sumoylation of HNRNPK, a p53/TP53 transcriptional coactivator, hence indirectly regulates p53/TP53 transcriptional activation resulting in p21/CDKN1A expression. Monosumoylates ZNF131 (PubMed:22825850).|
|Cellular Location||Nucleus. Nucleus speckle. Note=Localization to nuclear polycomb bodies is required for ZNF131 sumoylation (PubMed:22467880). Localized in distinct foci on chromatin (PubMed:18927235).|
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Provided below are standard protocols that you may find useful for product applications.
1.Cell Stem Cell. 2011 Sep 2;9(3):233-46.2.Ann Surg Oncol. 2013 Dec;20 Suppl 3:S684-92.
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