|Application ||WB, FC, ICC, E|
|Description||The protein encoded by this gene contains a THAP domain, a conserved DNA-binding domain. This protein colocalizes with the apoptosis response protein PAWR/PAR-4 in promyelocytic leukemia (PML) nuclear bodies, and functions as a proapoptotic factor that links PAWR to PML nuclear bodies. Alternatively spliced transcript variants encoding distinct isoforms have been observed.|
|Immunogen||Purified recombinant fragment of human THAP1 (AA: 1-213) expressed in E. Coli.|
|Formulation||Purified antibody in PBS with 0.05% sodium azide|
|Other Names||THAP domain-containing protein 1, THAP1|
WB~~1/500 - 1/2000
IF~~1/200 - 1/1000
FC~~1/200 - 1/400
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||THAP1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||DNA-binding transcription regulator that regulates endothelial cell proliferation and G1/S cell-cycle progression. Specifically binds the 5'-[AT]NTNN[GT]GGCA[AGT]-3' core DNA sequence and acts by modulating expression of pRB-E2F cell-cycle target genes, including RRM1. Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1. May also have pro-apoptopic activity by potentiating both serum-withdrawal and TNF-induced apoptosis.|
|Cellular Location||Nucleus, nucleoplasm. Nucleus, PML body|
|Tissue Location||Highly expressed in heart, skeletal muscle, kidney and liver. Weaker expression in brain and placenta|
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1.Mov Disord. 2014 Feb;29(2):278-80.2.Hum Mutat. 2011 Nov;32(11):1213-24.
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