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CBX2 Antibody

Purified Mouse Monoclonal Antibody

  • E - CBX2 Antibody AO2139a

    Black line: Control Antigen (100 ng);
    Purple line: Antigen(10ng);
    Blue line: Antigen (50 ng);
    Red line: Antigen (100 ng);

  • WB - CBX2 Antibody AO2139a

    Figure 2:Western blot analysis using CBX2 mAb against human CBX2 (AA: 402-525) recombinant protein. (Expected MW is 38.2 kDa)

  • WB - CBX2 Antibody AO2139a

    Figure 3:Western blot analysis using CBX2 mAb against HEK293 (1) and CBX2 (AA: 402-525)-hIgGFc transfected HEK293 (2) cell lysate.

  • WB - CBX2 Antibody AO2139a

    Figure 4:Western blot analysis using CBX2 mouse mAb against HUVEC (1), HEK293 (2), Hela (3), NIH/3T3 (4), and A431 (5) cell lysate.

  • IF - CBX2 Antibody AO2139a

    Figure 5:Immunofluorescence analysis of MCF-7 cells using CBX2 mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin. Secondary antibody from Fisher (Cat#: 35503)

  • FC - CBX2 Antibody AO2139a

    Figure 6:Flow cytometric analysis of HeLa cells using CBX2 mouse mAb (green) and negative control (red).

  • IHC - CBX2 Antibody AO2139a

    Figure 7:Immunohistochemical analysis of paraffin-embedded cervical cancer tissues using CBX2 mouse mAb with DAB staining.

  • IHC - CBX2 Antibody AO2139a

    Figure 8:Immunohistochemical analysis of paraffin-embedded rectum cancer tissues using CBX2 mouse mAb with DAB staining.

Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q14781
Reactivity Human, Mouse
Host Mouse
Clonality Monoclonal
Clone Names 4C11B10
Isotype IgG1
Calculated MW 56kDa
Description This gene encodes a component of the polycomb multiprotein complex, which is required to maintain the transcriptionally repressive state of many genes throughout development via chromatin remodeling and modification of histones. Disruption of this gene in mice results in male-to-female gonadal sex reversal. Mutations in this gene are also associated with gonadal dysgenesis in humans. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.
Immunogen Purified recombinant fragment of human CBX2 (AA: 402-525) expressed in E. Coli.
Formulation Purified antibody in PBS with 0.05% sodium azide
Additional Information
Gene ID 84733
Other Names Chromobox protein homolog 2, CBX2
Dilution E~~1/10000
WB~~1/500 - 1/2000
IF~~1/200 - 1/1000
FC~~1/200 - 1/400
IHC~~1/200 - 1/1000
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsCBX2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CBX2
Function Component of a Polycomb group (PcG) multiprotein PRC1- like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development (PubMed:21282530). PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:21282530). Binds to histone H3 trimethylated at 'Lys-9' (H3K9me3) or at 'Lys-27' (H3K27me3) (By similarity). Plays a role in the lineage differentiation of the germ layers in embryonic development (By similarity). Involved in sexual development, acting as activator of NR5A1 expression (PubMed:19361780).
Cellular Location Nucleus. Chromosome. Note=Localized in distinct foci on chromatin and in chromocenters. Localizes to the inactive X chromosome. Seems to be recruited to H3K27me3, H3K9ac and H3K3me2 sites on chromatin.
Citations (0)

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1.Br J Cancer. 2014 Oct 14;111(8):1663-72.2.Fertil Steril. 2013 Mar 1;99(3):819-826.

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$ 385.00
Cat# AO2139a
Availability: 7-10 days
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