|Application ||WB, IHC, E|
|Description||ATG13 (Autophagy Related 13) is a Protein Coding gene. Among its related pathways are Senescence and Autophagy and mTOR signaling pathway. GO annotations related to this gene include protein kinase binding.|
|Immunogen||Purified recombinant fragment of human ATG13 (AA: 339-550) expressed in E. Coli.|
|Formulation||Purified antibody in PBS with 0.05% sodium azide|
|Other Names||Autophagy-related protein 13, ATG13, KIAA0652|
WB~~1/500 - 1/2000
IHC~~1/200 - 1/1000
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ATG13 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Autophagy factor required for autophagosome formation and mitophagy. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1- RB1CC1 complex. Through its regulation of ULK1 activity, plays a role in the regulation of the kinase activity of mTORC1 and cell proliferation.|
|Cellular Location||Cytoplasm, cytosol. Preautophagosomal structure. Note=Under starvation conditions, is localized to puncate structures primarily representing the isolation membrane; the isolation membrane sequesters a portion of the cytoplasm resulting in autophagosome formation|
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1.Mol Biol Cell. 2009 Apr;20(7):1992-2003. 2.Mol Cell Biol. 2009 Jan;29(1):157-71.
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