|Application ||WB, IHC, FC, ICC, E|
|Description||The protein encoded by this gene is involved in the conversion of tyrosine to dopamine. It is the rate-limiting enzyme in the synthesis of catecholamines, hence plays a key role in the physiology of adrenergic neurons. Mutations in this gene have been associated with autosomal recessive Segawa syndrome. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.|
|Immunogen||Purified recombinant fragment of human TH (AA: 44-208) expressed in E. Coli.|
|Formulation||Purified antibody in PBS with 0.05% sodium azide|
|Other Names||Tyrosine 3-monooxygenase, 22.214.171.124, Tyrosine 3-hydroxylase, TH, TH, TYH|
WB~~1/500 - 1/2000
IF~~1/200 - 1/1000
FC~~1/200 - 1/400
IHC~~1/200 - 1/1000
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||TH Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Plays an important role in the physiology of adrenergic neurons.|
|Tissue Location||Mainly expressed in the brain and adrenal glands|
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1.Neurosci Lett. 2014 Jan 24;559:39-43.2.Biochem Biophys Res Commun. 2011 Nov 4;414(4):712-8.
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