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OTUD4 Antibody

Purified Mouse Monoclonal Antibody

  • E - OTUD4 Antibody AO2224a

    Figure 1:Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)

  • WB - OTUD4 Antibody AO2224a

    Figure 2:Western blot analysis using OTUD4 mAb against human OTUD4 (AA: 815-1049) recombinant protein. (Expected MW is 52.2 kDa)

  • WB - OTUD4 Antibody AO2224a

    Figure 3:Western blot analysis using OTUD4 mAb against HEK293 (1) and OTUD4 (AA: 815-1049)-hIgGFc transfected HEK293 (2) cell lysate.

  • WB - OTUD4 Antibody AO2224a

    Figure 4:Western blot analysis using OTUD4 mouse mAb against HepG2 (1) and C6 (2) cell lysate.

  • FC - OTUD4 Antibody AO2224a

    Figure 5:Flow cytometric analysis of Hela cells using OTUD4 mouse mAb (green) and negative control (red).

Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q01804
Reactivity Human, Rat
Host Mouse
Clonality Monoclonal
Clone Names 3B12G11
Isotype IgG1
Calculated MW 124kDa
Description Alternatively spliced transcript variants have been found for this gene. The smaller protein isoform encoded by the shorter transcript variant is found only in HIV-1 infected cells.
Immunogen Purified recombinant fragment of human OTUD4 (AA: 815-1049) expressed in E. Coli.
Formulation Purified antibody in PBS with 0.05% sodium azide
Additional Information
Gene ID 54726
Other Names OTU domain-containing protein 4,, HIV-1-induced protein HIN-1, OTUD4, HIN1, KIAA1046
Dilution E~~1/10000
WB~~1/500 - 1/2000
FC~~1/200 - 1/400
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsOTUD4 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name OTUD4 (HGNC:24949)
Function Deubiquitinase which hydrolyzes the isopeptide bond between the ubiquitin C-terminus and the lysine epsilon-amino group of the target protein (PubMed:23827681, PubMed:25944111, PubMed:29395066). May negatively regulate inflammatory and pathogen recognition signaling in innate immune response. Upon phosphorylation at Ser-202 and Ser-204 residues, via IL-1 receptor and Toll-like receptor signaling pathway, specifically deubiquitinates 'Lys-63'-polyubiquitinated MYD88 adapter protein triggering down-regulation of NF-kappa-B-dependent transcription of inflammatory mediators (PubMed:29395066). Independently of the catalytic activity, acts as a scaffold for alternative deubiquitinases to assemble specific deubiquitinase-substrate complexes. Associates with USP7 and USP9X deubiquitinases to stabilize alkylation repair enzyme ALKBH3, thereby promoting the repair of alkylated DNA lesions (PubMed:25944111).
Cellular Location Cytoplasm. Nucleus. Note=Primarily cytoplasmic
Research Areas
Citations (0)

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1.EMBO J. 2015 Jun 12;34(12):1687-703.

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$ 385.00
Cat# AO2224a
Availability: 7-10 days
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