|Application ||WB, E|
|Description||There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The intestinal alkaline phosphatase gene encodes a digestive brush-border enzyme. This enzyme is upregulated during small intestinal epithelial cell differentiation.|
|Immunogen||Purified recombinant fragment of human ALPI (AA: 397-458) expressed in E. Coli.|
|Formulation||Purified antibody in PBS with 0.05% sodium azide|
|Other Names||Paired box protein Pax-3, HuP2, PAX3, HUP2|
WB~~1/500 - 1/2000
FC~~1/200 - 1/400
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||PAX3 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Transcription factor that may regulate cell proliferation, migration and apoptosis. Involved in neural development and myogenesis. Transcriptional activator of MITF, acting synergistically with SOX10 (PubMed:21965087).|
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1. Virchows Arch. 2012 Feb;460(2):157-61. 2. World J Gastroenterol. 2012 Jul 7;18(25):3254-9.
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