|Application ||WB, IHC, FC, ICC, E|
|Description||The protein encoded by this gene is a member of the zinc finger family of proteins. The gene product contains C2H2-type domains, which are the classical zinc finger domains found in numerous nucleic acid-binding proteins. This protein functions as a regulator of the non-canonical NF-kappaB pathway in lymphotoxin-beta receptor signaling. Alternative splicing results in multiple transcript variants. A read-through transcript variant composed of ZFP91 and the downstream CNTF gene sequence has been identified, but it is thought to be non-coding. Read-through transcription of ZFP91 and CNTF has also been observed in mouse. A ZFP91-related pseudogene has also been identified on chromosome 2.;|
|Immunogen||Purified recombinant fragment of human ZFP91 (AA: 162-304) expressed in E. Coli.|
|Formulation||Purified antibody in PBS with 0.05% sodium azide|
|Application Note||ELISA: 1/10000|
WB: 1/500 - 1/2000
IHC: 1/200 - 1/1000
ICC: 1/100 - 1/500
FCM: 1/200 - 1/400
|Other Names||PZF; DMS-8; DSM-8; FKSG11; ZFP-91; ZNF757|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Mouse Monoclonal Antibody to ZFP91 is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Atypical E3 ubiquitin-protein ligase that mediates 'Lys- 63'-linked ubiquitination of MAP3K14/NIK, leading to stabilize and activate MAP3K14/NIK. It thereby acts as an activator of the non- canonical NF-kappa-B2/NFKB2 pathway. May also play an important role in cell proliferation and/or anti-apoptosis.|
|Tissue Location||Expressed ubiquitously, particularly at high level in testis. Isoform 2 is testis specific|
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1.Pathol Oncol Res. 2014 Apr;20(2):453-9. ; 2.Biochem Biophys Res Commun. 2010 Oct 1;400(4):581-6.;
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