|Application ||WB, IHC, FC, E|
|Reactivity||Human, Mouse, Rat, Monkey|
|Description||This gene encodes a member of the type I (acidic) cytokeratin family, which belongs to the superfamily of intermediate filament (IF) proteins. Keratins are heteropolymeric structural proteins which form the intermediate filament. These filaments, along with actin microfilaments and microtubules, compose the cytoskeleton of epithelial cells. Mutations in this gene are associated with epidermolytic hyperkeratosis. This gene is located within a cluster of keratin family members on chromosome 17q21.;|
|Immunogen||Purified recombinant fragment of human KRT10 (AA: 345-454 ) expressed in E. Coli.|
|Formulation||Purified antibody in PBS with 0.05% sodium azide|
|Application Note||ELISA: 1/10000|
WB: 1/500 - 1/2000
IHC: 1/200 - 1/1000
FCM: 1/200 - 1/400
|Other Names||BIE; EHK; K10; KPP; BCIE; CK10|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Mouse Monoclonal Antibody to KRT10 is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Plays a role in the establishment of the epidermal barrier on plantar skin.|
|Cellular Location||Secreted, extracellular space. Note=Localized on the surface of desquamated nasal epithelial cells.|
|Tissue Location||Seen in all suprabasal cell layers including stratum corneum|
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Provided below are standard protocols that you may find useful for product applications.
1.JAMA Dermatol. 2015 Jan;151(1):64-9. ; 2.Histopathology. 2012 Nov;61(5):910-20. ;
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