|Application ||WB, FC, E|
|Description||This gene encodes a transcriptional regulator that belongs to the BET (bromodomains and extra terminal domain) family of proteins. This protein associates with transcription complexes and with acetylated chromatin during mitosis, and it selectively binds to the acetylated lysine-12 residue of histone H4 via its two bromodomains. The gene maps to the major histocompatability complex (MHC) class II region on chromosome 6p21.3, but sequence comparison suggests that the protein is not involved in the immune response. This gene has been implicated in juvenile myoclonic epilepsy, a common form of epilepsy that becomes apparent in adolescence. Multiple alternatively spliced variants have been described for this gene.;|
|Immunogen||Purified recombinant fragment of human BRD2 (AA: 227-364) expressed in E. Coli.|
|Formulation||Purified antibody in PBS with 0.05% sodium azide|
|Application Note||ELISA: 1/10000|
WB: 1/500 - 1/2000
FCM: 1/200 - 1/400
|Other Names||FSH; NAT; RNF3; FSRG1; RING3; D6S113E; O27.1.1|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Mouse Monoclonal Antibody to BRD2 is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May play a role in spermatogenesis or folliculogenesis (By similarity). Binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling. Regulates transcription of the CCND1 gene. Plays a role in nucleosome assembly.|
|Cellular Location||Nucleus. Note=Detected on chromatin and nucleosomes|
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1.Mol Biol Cell. 2013 Nov;24(22):3557-68. ; 2.J Biol Chem. 2010 Mar 5;285(10):7610-8.;
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