|Application ||WB, IHC-P, E|
|Calculated MW||25503 Da|
|Antigen Region||48-74 aa|
|Other Names||Metalloproteinase inhibitor 4, Tissue inhibitor of metalloproteinases 4, TIMP-4, TIMP4|
|Target/Specificity||This TIMP4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 48-74 amino acids from the Central region of human TIMP4.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||TIMP4 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Known to act on MMP-1, MMP-2, MMP-3, MMP-7 and MMP- 9.|
|Tissue Location||Abundant in heart and present at low levels in many other tissues|
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Provided below are standard protocols that you may find useful for product applications.
This gene belongs to the TIMP gene family. The proteins encoded by this gene family are inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix. The secreted, netrin domain-containing protein encoded by this gene is involved in regulation of platelet aggregation and recruitment and may play role in hormonal regulation and endometrial tissue remodeling.
Nalpas, B., et al. Gut 59(8):1120-1126(2010)
Bailey, S.D., et al. Diabetes Care (2010) In press :
Wojciechowski, R., et al. Invest. Ophthalmol. Vis. Sci. (2010) In press :
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
Liss, M., et al. Am. J. Pathol. 175(3):940-946(2009)
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