|Application ||WB, E|
|Other Accession||D3ZUI5, NP_056013.2|
|Calculated MW||135617 Da|
|Antigen Region||184-211 aa|
|Other Names||Protein cordon-bleu, COBL, KIAA0633|
|Target/Specificity||This COBL antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 184-211 amino acids from the N-terminal region of human COBL.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||COBL Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Plays an important role in the reorganization of the actin cytoskeleton. Regulates neuron morphogenesis and increases branching of axons and dendrites. Regulates dendrite branching in Purkinje cells (By similarity). Binds to and sequesters actin monomers (G actin). Nucleates actin polymerization by assembling three actin monomers in cross-filament orientation and thereby promotes growth of actin filaments at the barbed end. Can also mediate actin depolymerization at barbed ends and severing of actin filaments. Promotes formation of cell ruffles.|
|Cellular Location||Cell membrane; Peripheral membrane protein; Cytoplasmic side Cytoplasm, cytoskeleton. Cell projection, ruffle. Cytoplasm. Note=Recruited to the cell membrane via interaction with PACSIN1. Colocalizes with the actin cytoskeleton. Detected throughout the neuron cell body, as well as in axons and dendrites (By similarity).|
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Provided below are standard protocols that you may find useful for product applications.
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Trynka, G., et al. Gut 58(8):1078-1083(2009)
Barrett, J.C., et al. Nat. Genet. (2009) In press :
de Krom, M., et al. Biol. Psychiatry 65(7):625-630(2009)
Ballif, B.A., et al. Mol. Cell Proteomics 3(11):1093-1101(2004)
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