|Application ||WB, IHC-P, E|
|Other Accession||Q9DCR2, Q2YDH6, NP_001275.1|
|Calculated MW||21732 Da|
|Antigen Region||1-30 aa|
|Other Names||AP-3 complex subunit sigma-1, AP-3 complex subunit sigma-3A, Adaptor-related protein complex 3 subunit sigma-1, Clathrin-associated/assembly/adaptor protein, small 3, Sigma-3A-adaptin, Sigma3A-adaptin, Sigma-adaptin 3a, AP3S1, CLAPS3|
|Target/Specificity||This AP3S1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human AP3S1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||AP3S1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals.|
|Cellular Location||Golgi apparatus. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side Note=Component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex|
|Tissue Location||Present in all adult tissues examined.|
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Provided below are standard protocols that you may find useful for product applications.
Part of the AP-3 complex, an adapter-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes.
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Zhou, J.B., et al. Med. Sci. Monit. 16 (6), BR179-BR183 (2010) :
Lefrancois, S., et al. Dev. Cell 7(4):619-625(2004)
Salazar, G., et al. Mol. Biol. Cell 15(2):575-587(2004)
Nie, Z., et al. Dev. Cell 5(3):513-521(2003)
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