|Application ||WB, E|
|Other Accession||Q4R4A2, NP_659499.2|
|Reactivity||Human, Hamster, Mouse|
|Calculated MW||65959 Da|
|Antigen Region||107-136 aa|
|Other Names||Zinc finger with UFM1-specific peptidase domain protein, ZUFSP, C6orf113|
|Target/Specificity||This ZUFSP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 107-136 amino acids from the N-terminal region of human ZUFSP.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ZUFSP Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Deubiquitinase with endodeubiquitinase activity that specifically interacts with and cleaves 'Lys-63'-linked long polyubiquitin chains. Shows only weak activity against 'Lys-11' and 'Lys-48'-linked chains (PubMed:29576528, PubMed:29563501, PubMed:29476094). Plays an important role in genome stability pathways, functioning to prevent spontaneous DNA damage and also promote cellular survival in response to exogenous DNA damage (PubMed:29576528, PubMed:29576527). Modulates the ubiquitination status of replication protein A (RPA) complex proteins in response to replication stress (PubMed:29563501).|
|Cellular Location||Cytoplasm. Nucleus. Note=Mostly present in the nuclear fraction. Localizes to DNA lesions.|
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Mungall, A.J., et al. Nature 425(6960):805-811(2003)
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